Every profession typically comes with its unique or specific set of challenges, especially during practice. My most challenging nursing assignment as a student nurse was to provide care to three patients admitted in the oncology unit at the Jackson Memorial Hospital. These patients included two male patients, one with pancreatic cancer and the other with sickle cell crisis, and a female patient with carcinoma/portal vein obstruction, and suspected jaundice with ammonia stabilized at a level of 22 as per her last check-up. I was tasked with the duty of delivering care, particularly pain management, under the supervision of my preceptor. I perceive this as my most difficult assignment because this was my first time in the oncology unit, particularly chemotherapy and I had never encountered patients diagnosed with chronic pain following a medical procedure and the underlying health conditions.